Transcriptional interference among the murine ß-like globin genes
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منابع مشابه
Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β-like globin genes.
The clinical symptoms of hemoglobin disorders such as β-thalassemia and sickle cell anemia are significantly ameliorated by the persistent expression of γ-globin after birth. This knowledge has driven the discovery of important regulators that silence γ-globin postnatally. Improved understanding of the γ- to β-globin switching mechanism holds the key to devising targeted therapies for β-hemoglo...
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1Department of Microbiology/Immunology and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH; 2Department of Medicine, Division of Hematology, Albert Einstein College of Medicine, Bronx, NY; 3Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor; 4Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, ...
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There is little evidence addressing the role of CpG methylation in transcriptional control of genes that do not contain CpG islands. This is reflected in the ongoing debate about whether CpG methylation merely suppresses retroelements or if it also plays a role in developmental and tissue-specific gene regulation. The genes of the beta-globin locus are an important model of mammalian developmen...
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Mammalian -globin loci contain multiple -like genes that are expressed at different times during development. The murine -globin locus contains two genes expressed during the embryo stage, Ey and h1, and two genes expressed at both the fetal and postnatal stages, -major and -minor. Studies of transgenic human -like globin loci in mice have suggested that expression of one gene at the locus will...
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We have characterized mRNA expression and transcription of the mouse aand b-globin loci during development. S1 nuclease and primary transcript in situ hybridization analyses demonstrate that all seven murine globin genes (z, a1, a2, ey, bH1, bmaj, and bmin) are transcribed during primitive erythropoiesis, however transcription of the z, ey, and bH1 genes is restricted to the primitive erythroid...
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تاریخ انتشار 2007